1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH) (乙醛脱氢酶)

醛脱氢酶 (ALDH) 是 NADP+ 依赖性酶的超家族,可将内源性和外源性醛代谢为相应的羧酸。该蛋白质超家族由 19 种同工酶组成,在大多数哺乳动物组织中观察到至少一种同工酶的组成活性。ALDH 在细胞解毒、防止紫外线引起的损伤以及氨基酸代谢等方面发挥着重要作用。

ALDH1A 亚家族通过介导视黄酸信号传导在胚胎发生和发育中起着关键作用。ALDH2 是氧化乙醛的关键酶,对酒精代谢至关重要。ALDH1A1 和 ALDH3A1 是晶状体和角膜晶状体蛋白,它们是细胞防御机制抵御紫外线引起的眼部组织损伤的重要组成部分。许多 ALDH 同工酶在氧化脂质过氧化产生的活性醛方面发挥着重要作用,从而有助于维持细胞稳态。据报道,在各种人类癌症中,ALDH 同工酶的表达和活性增加,并且与癌症复发有关。由于其重要的生理和毒理作用,人们开发了 ALDH 酶抑制剂来治疗人类疾病。

Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that metabolize endogenous and exogenous aldehydes to corresponding carboxylic acids. This superfamily of proteins is comprised of 19 isozymes, with constitutive activity of at least one isozyme observed in a majority of mammalian tissues. The ALDHs play important roles, among other things, in cellular detoxification, the protection against ultraviolet radiation-induced damage, and amino acid metabolism.

The ALDH1A subfamily plays a pivotal role in embryogenesis and development by mediating retinoic acid signaling. ALDH2, as a key enzyme that oxidizes acetaldehyde, is crucial for alcohol metabolism. ALDH1A1 and ALDH3A1 are lens and corneal crystallins, which are essential elements of the cellular defense mechanism against ultraviolet radiation-induced damage in ocular tissues. Many ALDH isozymes are important in oxidizing reactive aldehydes derived from lipid peroxidation and thereby help maintain cellular homeostasis. Increased expression and activity of ALDH isozymes have been reported in various human cancers and are associated with cancer relapse. As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-151229
    S-Methyl-N,N-diethylthiolcarbamate Inhibitor 99.77%
    S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) 是醛脱氢酶抑制剂双硫仑 (HY-B0240) 的活性代谢物。它由小鼠肝微粒体中双硫仑代谢物二乙基二硫代氨基甲酸甲基化而产生。S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me)可抑制大鼠肝脏低 Km 醛脱氢酶 (ALDH) (ID50=15.5 mg/kg)。当以 20.6 mg/kg 的剂量给药时,它会降低大鼠平均动脉压 (MAP) 并增加大鼠在乙醇刺激期间的心率。
    S-Methyl-N,N-diethylthiolcarbamate
  • HY-148243
    IGUANA-1 free base Inhibitor 99.69%
    IGUANA-1 free base (STL5-T-0057) 是 ALDH1 B1 的选择性抑制剂,IC50 值为 30 nM。IGUANA-1 free base 抑制 SW480 细胞生长在附着或球形条件下,IC50 值分别为 2.46 和 0.39 μM。IGUANA-1 free base 可用于癌症的研究。
    IGUANA-1 free base
  • HY-157567
    FSI-TN42 Inhibitor 98.05%
    FSI-TN42 (N42) 是一种选择性、口服活性且不可逆的 ALDH1A1 抑制剂,IC50 为 23 nM。FSI-TN42 对 ALDH1A1 的抑制作用比对 ALDH1A2 (IC50
    FSI-TN42
  • HY-N1177
    Taraxerone

    蒲公英赛酮

    Inhibitor 99.95%
    Taraxerone 是从垂盆草中分离出来的。Taraxerone 增强乙醇脱氢酶 (ADH) 和乙醛脱氢酶 (ALDH) 活性,EC50 值分别为 512.42 μM 和 500.16 μM。
    Taraxerone
  • HY-121970
    iGP-1 Inhibitor
    iGP-1 是一种细胞渗透性的线粒体 sn-甘油3-磷酸脱氢酶 (mGPDH) 选择性抑制剂。iGP-1 抑制 mGPDH 产生的 H2O2
    iGP-1
  • HY-139031
    ALDH1A2-IN-1 Inhibitor 98.80%
    ALDH1A2-IN-1 是一种活性位点导向的可逆 ALDH1A2 抑制剂(IC50=0.91 μM; Kd=0.26 μM),ALDH1A2-IN-1 具有多种疏水相互作用。
    ALDH1A2-IN-1
  • HY-126241
    RV01 Inhibitor 98.06%
    RV01 是白藜芦醇类似物,可抑制 DNA 损伤,降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达,具有清除羟自由基的活性。RV01 降低 iNOS 的表达,具有抗神经炎症作用。
    RV01
  • HY-N0018R
    Daidzin (Standard)

    大豆苷 (Standard)

    Inhibitor
    Daidzin (Standard) 是 Daidzin 的分析标准品。本产品用于研究及分析应用。大豆苷 (Daidzin) 是一种异黄酮具有抗氧化,抗癌,抗动脉粥样硬化活性。Daidzin 是一种有效的、选择性的线粒体 ALDH-2 抑制剂。Daidzin 减少乙醇消耗。
    Daidzin (Standard)
  • HY-N7083R
    Citral (Standard)

    柠檬醛 (Standard)

    Inhibitor
    Citral (Standard) 是 Citral 的分析标准品。本产品用于研究及分析应用。Citral 是一种口服有效的柠檬草精油中的单萜化合物和天然 ALDH1A 抑制剂,可以诱导乳腺癌细胞系发生细胞凋亡和周期停滞,具有镇痛、抗伤害和抗炎作用[2][3]
    Citral (Standard)
  • HY-RS00570
    Aldh2 Rat Pre-designed siRNA Set A Inhibitor
    Aldh2 Rat Pre-designed siRNA Set A 包括针对 Aldh2 (Rat) 基因的不同区域设计三对 siRNA,以及阴性对照、FAM 标记阴性对照和阳性对照。
    Aldh2 Rat Pre-designed siRNA Set A
    Aldh2 Rat Pre-designed siRNA Set A
  • HY-RS00561
    Aldh1a1 Mouse Pre-designed siRNA Set A Inhibitor
    Aldh1a1 Mouse Pre-designed siRNA Set A 包括针对 Aldh1a1 (Mouse) 基因的不同区域设计三对 siRNA,以及阴性对照、FAM 标记阴性对照和阳性对照。
    Aldh1a1 Mouse Pre-designed siRNA Set A
    Aldh1a1 Mouse Pre-designed siRNA Set A
  • HY-18768A
    NCT-501 hydrochloride Inhibitor
    NCT-501 hydrochloride 是一种茶碱类的有效醛脱氢酶 1A1 (ALDH1A1) 选择性抑制剂,抑制 hALDH1A1 时 IC50 值为 40 nM,选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时, IC50 值 >57 μM)。
    NCT-501 hydrochloride
  • HY-142708
    α-Pyridoin Inhibitor
    α-Pyridoin是一种独特的烯二醇抗氧化剂。
    α-Pyridoin
  • HY-RS00569
    Aldh2 Mouse Pre-designed siRNA Set A Inhibitor
    Aldh2 Mouse Pre-designed siRNA Set A 包括针对 Aldh2 (Mouse) 基因的不同区域设计三对 siRNA,以及阴性对照、FAM 标记阴性对照和阳性对照。
    Aldh2 Mouse Pre-designed siRNA Set A
    Aldh2 Mouse Pre-designed siRNA Set A
  • HY-148617
    ALDH2 modulator 1 Modulator
    ALDH2 modulator 1 是一种有效的具有口服活性的乙醛脱氢酶-2 ALDH2 调节剂。ALDH2 modulator 1 可降低小鼠血液中的酒精含量。
    ALDH2 modulator 1
  • HY-76006R
    3-Hydroxybenzaldehyde (Standard)

    间羟基苯甲醛 (Standard)

    3-Hydroxybenzaldehyde (Standard)是 3-Hydroxybenzaldehyde 的分析标准品。本产品用于研究及分析应用。3-Hydroxybenzaldehyde 是 Protocatechuic aldehyde (PCA) (HY-N0295) 等酚类化合物的前体化合物。3-Hydroxybenzaldehyde,由 3-hydroxybenzyl-alcohol 脱氢酶产生,是大鼠和人醛脱氢酶 (ALDH) 的底物 (substrate)。3-Hydro
    3-Hydroxybenzaldehyde (Standard)
  • HY-144671
    ALDH3A1-IN-2 Inhibitor
    ALDH3A1-IN-2 (Compound 19) 是一种有效的 ALDH3A1 抑制剂,IC50 为 1.29 μM。醛脱氢酶 (ALDH) 在包括前列腺癌在内的各种肿瘤类型中过度表达。ALDH3A1-IN-2 具有研究癌症疾病的潜力。
    ALDH3A1-IN-2
  • HY-N11451
    Lacto-N-fucopentaose III Activator
    Lacto-N-fucopentaose III (LNFP-III) 是一种免疫调节剂。Lacto-N-fucopentaose III 可降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度。
    Lacto-N-fucopentaose III
  • HY-146240
    ALDH1A1-IN-3 Inhibitor
    ALDH1A1-IN-3 (compound 57) 是一种良好且具有选择性的醛脱氢酶 1A1 (ALDH1A1) 抑制剂,IC50 为 0.379 μM。ALDH1A1-IN-3 能有效改善 HepG2 细胞的葡萄糖消耗。ALDH1A1-IN-3 可用于改善糖代谢的研究。
    ALDH1A1-IN-3
  • HY-122373
    Coprine Inhibitor
    Coprine 是一种霉菌毒素,从普通墨帽菌 Coprinopsis atramentaria 中分离得到。Coprine 是一种乙醛脱氢酶抑制剂,导致乙醛的积聚,引起酒精脸红反应。
    Coprine
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